2 different gpus

[DuTch_PriDeZ_17]

Hello there,
I share a computer with my brother by using Aster. He only plays League of Legends but i want to play more gpu intensive games. My current setup is: Cpu: Amd ryzen 5 2600x, Gpu: 2x nvidia geforce gtx 760 ( 1 per person), Ram: 16 gb Motherboard: asrock fatality b450 gaming
Psu: seasonic S12II-520 bronze 520 watt.
I want to upgrade my gpu but my brother's gpu doesn't need an upgrade. I asked the guy that builds my pc if there can be 2 different GPU's in the same system and he said that is wasn't recommended, but I can't afford to upgrade both. I want to upgrade to an amd radeon rx 5700. So my question is; will Aster be able to run whilst having 2 different gpu's?

[blastradius32]

I run Aster with a Vega 64 and an RX 580.

[rezfinalmardhan]

I also run aster with 2 gpu, Intel UHD 630 and NVidia GPU
But I've a problem on playing GTA V, it can be run on Terminal with the NVidia GPU but It cant run on Terminal with Intel UHD 630, meanwhile after I disabled the Aster or the NVIdia GPU i can run it on the Terminal with Intel UHD 630. Have you guys who use Internal graphic and External Graphic try it??